In terms of MHC course We antigen speech, cTECs express a unique catalytic subunit of proteasome referred to as I?5t Proteasomes that include I?5t include named a€?thymoproteasomesa€™. They’ve a substrate preference which distinct from proteasomes that contain the I?5 or I?5i subunits 4 (termed a€?housekeeping proteasomesa€™ and a€?immunoproteasomesa€™, correspondingly). Mice missing thymoproteasomes reveal a substantial